Over the last decade, the proteome array platform developed at UC Irvine has become a popular tool for the discovery of antigens recognized antibodies in immune sera. The information generated is used to develop serodiagnostic tests, design subunit vaccines and monitor infectious diseases through seroepidemiological studies. The lab, with Philip Felgner as PI, has produced proteome arrays for over 30 human pathogens, from virus and bacteria to metazoan parasites.
The UCI lab collaborates with many investigators in countries around the world where infectious diseases have a significant impact on human health. The desire by many investigators to do their own array studies ‘in-house’, coupled with the difficulties of shipping sera from some countries and the ever increasing demand for arrays, has led to the development of this site.
The aim is to empower individuals to perform their own array probing and data analysis. You may be a new associate in the UCI lab, or someone on the other side of the world. Either way, here you will find protocols, methods and resources to help you do hit the ground running. I hope you will find this site a useful resource and welcome your suggestions for improvements.
Huw Davies
Huw's Proteome Microarrays User Manual 